Buclizine is an antihistamine (to treat allergies and hypersensitive reactions and colds) and anticholinergic (to block the action of acetylcholine) of the piperazine derivative class. It is believed to be an antiemetic, identical to Meclizine. In the United Kingdom, Buclizine is one of three medications incorporated in Migraleve pills, promoted by McNeil Healthcare for migraine sufferers.

Drug Indications

Buclizine is indicated for the prophylaxis or prevention of nausea, vomiting, and lightheadedness connected with motion sickness (kinetosis). It is a condition of being lightheaded or sickened due to the motions that take place while journeying in or on a moving vehicle

Mechanism of Action/Effect

The method by which Buclizine wields its antiemetic (a medication that prevents or eases nausea and vomiting) and antimotion illness upshots is not specifically identified, but may be associated with its key anticholinergic activities. It lessens vestibular stimulation and presses labyrinthine action down. An execution on the medullary chemoreceptive activation area may also be incorporated in the antiemetic effect.

Buclizine also boasts antihistaminic, anticholinergic, anti-dizziness, central nervous system (CNS) sedative, and topical anesthetic effects.

Allergic Reactions

Speak to your general practitioner if you have ever experienced any abnormal allergic reaction to Buclizine. Also inform your healthcare provider if you are hypersensitive to any other items, for example foods, chemical additives, or dyestuffs.

Pregnancy

Buclizine has not been demonstrated to bring forth birth abnormalities or other troubles in human beings. Nevertheless, researches in animals have established that Buclizine, Cyclizine, and Meclizine administered in dosages multiple times the normal human dosage induce birth flaws, for instance cleft palate (a congenital fissure of the hard palate).

Breastfeeding

Even though Buclizine may release into breast milk, it has not been accounted for causing harms in breastfeeding infants. On the other hand, as it is liable to diminish the secretions within the body, it is likely that the stream of breast milk may be minified in a number of patients.

Use in Children

There is no particular data evaluating usage of Buclizine in different age groups. Nonetheless, children may be particularly susceptible to the anticholinergic impacts (such as xerostomia or dry mouth, nose, and throat) of this medication.

Other Problems

The existence of other medical conditions may have an effect upon the use of Buclizine. Make certain you let your general practitioner know if you suffer from any other medical troubles, specially:

• Asthma attack, bronchitis (a respiratory illness), pulmonary emphysema, or other degenerative lung disorders;
• Prostate enlargement;
• Glaucoma that harms the optic nerve and mars vision;
• Intestinal obstruction;
• Closure of urinary tract - Buclizine may deteriorate these conditions further; or
• Coronary failure.

Dosage & Administration

Buclizine is available in the form of chewable tablets to prevent the symptoms related to motion sickness. In case of adults and teenagers, the standard dosage is 50 mg taken half an hour prior to travel. If the requirement arises, it may be administered every 4 to 6 hours repeatedly. However, the maximum amount of Buclizine taken per day should not exceed 150 mg. For children below the age of 12, dosage should be determined by your physician.

Synonym

United States: Bucladin-S Softab
Switzerland: Longifene* Panzimine*
Singapore: Longifene*
South Africa: Longifene Postafeno
Portugal: Buclina
Mexico: Postavit-B* Longimin* Longifene*
Malaysia: Buchzine*
India: Longifene
Hong Kong: Longifene
France: Aphilan Postafen
Brazil: Buclina
Belgium: Longifene