Product Name : Clindac-A
Product Type : Clindamycin Phosphate Gel 1%
Manufacturer : Galderma India Pvt. Ltd., Mumbai
Packaging and Product : 10 gram tubes
Classification : Presciption Medication

Clindac-A - an overview
General Information
Clindamycin phosphate topical gel, 1% is a topical antibiotic approved for the treatment of acne vulgaris. This drug belongs to the class of antibiotics known as lincosamides. By inhibiting bacteria protein synthesis at the ribosomal level (the site of protein synthesis), clindamycin is believed to kill bacteria associated with acne.

The term "acne vulgaris" refers to the more common form of acne, consisting of non-inflammatory and mildly inflammatory lesions. The more severe form of acne is characterized by the presence of nodules. Nearly 17 million people in the United States have acne, making it the most common skin disease. Although acne is not a serious health threat, severe acne can lead to disfiguring, permanent scarring, which can be upsetting for people who suffer from the disorder.

Clinical Results
Trial results indicated that clindamycin phosphate gel was more effective than a vehicle gel in the treatment of mild to moderate acne vulgaris. The 12-week, multicenter, randomized, vehicle-controlled trial compared clindamycin phosphate topical gel, 1% once daily to a vehicle gel administered once daily.

The mean percent reduction in lesion counts at the end of treatment was 51% for clindamycin phosphate gel versus 40% for the vehicle gel for inflammatory lesions. For non-inflammatory lesions, the mean percent reduction was 25% for clindamycin phosphate gel and 12% for the vehicle gel. The total mean percent reduction in lesion counts at the end of treatment was 38% for clindamycin phosphate gel and 27% for the vehicle gel.

In a contact sensitization trial, four of the 200 subjects appeared to develop suggestive evidence of allergic contact sensitization to clindamycin phosphate gel. There was no signal for contact sensitization in the clinical trials under normal use conditions.

Side Effects
Adverse reactions associated with the use of clindamycin phosphate gel include itching and peeling skin.

Cases of diarrhea, bloody diarrhea, and colitis have been reported as adverse reactions in subjects treated with oral and parenteral (intravenous) formulations of clindamycin, and have been reported rarely with topical clindamycin. Abdominal pain and gastrointestinal disturbances, as well as gram-negative folliculitis (bacterial infection and inflammation of hair follicles), have also been reported in association with the use of topical formulations of clindamycin.

Mechanism of Action
Although clindamycin phosphate is inactive in vitro, rapid in vitro hydrolysis converts this compound to clindamycin which has antibacterial activity. Clindamycin inhibits bacteria protein synthesis at the ribosomal level by binding to the 50S ribosomal subunit and affecting the process of peptide chain initiation.

Synonym
Felisep Dalacin Clindox Clindaval
Venezuela: Bioclindax Evoclin Clindets Clindesse ClindaMax Clindagel Clinda-Derm¤ Cleocin Cleocin T
United States: C/T/S¤ Zindaclin Dalacin Dalacin T
United Kingdom: Dalacin C Rosil Lacin Klinna Klindan Klimicin Dalacin T Dalacin C Dacin-F Clinott
Thailand: Chinacin-T Dalacin V Dalacin T
Switzerland: Dalacin C
Sweden: Dalacin Dalacin
Spain: Clinwas Topicil Tidact¤ Dalacin T Dalacin C Clindatech Clindagel Climadan¤
Singapore: C-Mycin Dalacin VC Dalacin T Dalacin C Clindahexal
South Africa: Clindac Klimicin (Климицин) Dalacin C (Далацин Ц) Dalacin (Далацин)
Russia: Clindacin (Клиндацин) Dalacin V Dalacin T
Portugal: Dalacin C Topicil Dalacin V¤ Dalacin T¤ Dalacin C
New Zealand: Clinac¤
Norway: Dalacin Dalacin V¤ Dalacin T
Netherlands: Dalacin C Trexen Losertrin Lisiken Lindacil Klyndaken Indamid Galecin Damiclin Dalacin V Dalacin T Dalacin C Cutaclin Clindazyn Clidets Clendazaf Cigmadil
Mexico: Ancine Topicil Tidact Dalacin T Dalacin C
Malaysia: C-Mycin Dalacin T Dalacin C
Italy: Cleocin Zindaclin Dalagis T Dalacin Vaginal
Israel: Dalacin C Zindaclin Dalacin Dalacin T
Ireland: Dalacin C Dalcap Dalacin
India: Clindac A Klimicin Dalacin Dalacin T
Hungary: Dalacin C Topicil¤ Fleminosan¤ Delta T Dalacin V¤ Dalacin T Dalacin C Clindatech Clinac
Hong Kong: Claribel Ygielle Upderm Toliken Sotomycin Paradis Lindasol¤ Fouch Edason¤ Dalacin C Clindagel Clidacin Botamycin-N
Greece: Arfarel Zindaclin Turimycin Sobelin Jutaclin Dentomycin Clindastad Clindahexal Clindabeta Clinda Clinda-saar Clin-Sanorania Basocin
Germany: Aclinda¤ Zindacline Dalacine
France: Dalacine T
Finland: Dalacin
Denmark: Dalacin Klimicin Dalacin Dalacin T
Czech Republic: Dalacin C Lexis Divanon Dermabel Dalacin Dalacin V Dalacin T Dalacin C Daclin Cluvax
Chile: Clidets Dalacin Vaginal Dalacin T Dalacin C
Canada: Clindets Dalacin V Dalacin T Dalacin C Clindarix Clindamin C Clindacne Clindacin
Brazil: Clinagel Zindaclin Dalacin Vaginal Dalacin Topical
Belgium: Dalacin C Lanacine Dalacin Clindal¤ Clindac Clidam
Austria: Cleocin Dalacin V Dalacin T Dalacin C Clindatech
Australia: Cleocin Torgyn Naxoclinda Dalacin Dalacin ST Dalacin C Clintopic Clindopax Clindalaf Clindacin
Argentina: Acnestop

Generic Clindac-a Gel

Generic Cleocin-T, Erytop, Clindamycin Phosphate 1 % 20 gm Gel (USV) US Brand Name Cleocin-T Generic Name Clindamycin Phosphate Other Brand Name Mimosee, Erytop Manufacturer Intas, USV Packing 1 Form Gel Strength 1 % 20 gm

20g $3.99 Quantity 1 2 3 4 5 6 7 8 9 10

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