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Drug Mechanism: How does it work?
Glucotrol, Glipizide is an oral glucose-lowering drug in a class of medications
for diabetes called sulfonylureas.
Glipizide lowers blood sugar by stimulating the pancreas to secrete insulin
and helping the body use insulin efficiently. The pancreas must be capable of
producing insulin for Glipizide to work. Insulin is a hormone which lowers the
blood sugar level.
Approximately 90% of patients with diabetes has type II or non- insulin dependent diabetes mellitus. Type II diabetes usually
Dosage: How should you take Glucotrol?
In general, to achieve the best control over blood sugar levels, Glucotrol should
be taken 30 minutes before a meal. However, the exact Glucotrol dosing schedule
as well as the dosage amount must be determined by your physician.
Glucotrol XL should be taken with breakfast. Swallow the Glucotrol XL tablets
whole; do not chew, crush, or divide them. Do not be alarmed if you notice something
that looks like a tablet in your stool--it will be the empty shell that has
been eliminated.
How should you take Glucotrol?
Possible food and drug interactions when taking Glucotrol
It is essential that you closely follow your physician's dietary guidelines
and that you inform your physician of any medication, either prescription or
nonprescription, that you are taking. Specific medications that affect Glucotrol
include:
Airway-opening drugs such as Sudafed
Antacids such as Mylanta
Aspirin
Chloramphenicol (Chloromycetin)
Cimetidine (Tagamet)
Clofibrate (Atromid-S)
Corticosteroids such as prednisone (Deltasone)
Diuretics such as HydroDIURIL
Estrogens
Special information on Glucotrol
Special information if you are pregnant or breastfeeding:
The effects of Glucotrol during pregnancy have not been adequately studied.
Therefore, if you are pregnant, or planning to become pregnant, you should take
Glucotrol only on the advice of your physician. Since studies suggest the importance
of maintaining normal blood sugar (glucose) levels during pregnancy, your physician
may prescribe insulin during pregnancy. To minimize the risk of low blood sugar
in newborn babies, Glucotrol, if taken during pregnancy, should be
Glucotrol side effects
Side effects of Glucotrol are rare and seldom require discontinuation of the
medication.
More common side effects may include:
Constipation, diarrhea, dizziness, drowsiness, gas, headache, hives, itching,
low blood sugar, nervousness, sensitivity to light, skin rash and eruptions,
stomach pain, tremor.
Less common or rare side effects may include:
Anemia and other blood disorders, yellow eyes and skin.