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Generic Name: Nexium
Indications
GORD: Treatment of Reflux Oesophagitis (RO): 40mg once daily (od) for 4 weeks.
An additional 4 weeks treatment is recommended for patients in whom oesophagitis
has not healed or who have persistent symptoms. Long-term management of patients
with healed oesophagitis to prevent relapse: 20mg od. Symptomatic treatment
of GORD: 20mg od (in patients without oesophagitis). If symptoms have not been
controlled after 4 weeks, the patient should be further investigated. Once symptoms
have resolved, subsequent symptom control can be achieved using on-demand Nexium
20mg od, when needed.
Helicobacter pylori eradication (in combination with appropriate antibiotics): Healing of H. pylori associated duodenal ulcers and prevention of relapse of peptic ulcers in patients with H. pylori associated ulcbders. Nexium 20mg, amoxycillin 1g, clarithromycin 500mg, all twice daily for 7 days.
Renal impairment: No dose adjustment needed. Patients with severe renal insufficiency
should be treated with caution. Hepatic impairment: No dose adjustment needed
except in patients with severe liver impairment where a maximum daily dose of
20mg should not be exceeded.
Children: Nexium should not be used in children since no data is available.
CONTRA-INDICATIONS: Known hypersensitivity to esomeprazole, substituted benzimidazoles or any other constituents of Nexium.
WARNINGS AND PRECAUTIONS:
In the presence of any alarm symptoms and when gastric ulcer is suspected or
present, malignancy should be excluded, as treatment may alleviate symptoms
and delay diagnosis. Patients on long-term treatment should be kept under regular
surveillance. Patients on on-demabdnd treatment should contact their physician
if their symptoms change in character. When prescribing Nexium for on-demand
therapy, the implications for interactions with other pharmaceuticals should
be considered. When prescribing Nexium for H. pylori eradication, possible drug
interactions for all components in the triple therapy, particularly clarithromycin,
should be considered. Patients with rare hereditary problems of fructose intolerance,
glucose-galactose malabsorption or sucrase-isomaltase insufficiency should not
take this medicine.
Synonym
Venezuela: Nexium
United States: Nexium
United Kingdom: Nexium
Thailand: Nexium
Switzerland: Nexium
Sweden: Nexium Nexium
Spain: Axiago
Singapore: Nexium
South Africa: Nexiam
Russia: Nexium (Нексиум)
Portugal: Nexium
Norway: Nexium
Netherlands: Nexium
Mexico: Nexium
Malaysia: Nexium Nexium Lucen Esopral
Italy: Axagon
Israel: Nexium
Ireland: Nexium Sompraz Esoz
India: Esomac
Hungary: Nexium
Hong Kong: Nexium
Greece: Nexium
Germany: Nexium
France: Inexium
Finland: Nexium
Denmark: Nexium
Czech Republic: Nexium
Chile: Nexium
Canada: Nexium
Brazil: Nexium
Belgium: Nexiam
Austria: Nexium
Australia: Nexium
Argentina: Nexium
